A woman who was killed by an out-of-control car in Melbourne last night was herself an emergency nurse at the Alfred hospital where she later died, it has been reported.
Distraught colleagues fought desperately to save the woman's life but her injuries were too severe, the Herald Sun reported.
Police said a Lexus coupe ran across tram tracks on Flinders Street to the wrong side of the road, struck a pole at the Elizabeth Street intersection and hit three women at about 7.30pm (AEDT) on Wednesday.
The woman's two friends were treated at the Royal Melbourne Hospital for minor injuries.
Nurses at the Alfred were last night reportedly overcome by emotion as they grappled with the death of their colleague, described by one as a "wonderful" workmate.
The male driver and his female passenger were taken to hospital with minor injuries.
Police will question them when they are released.
Tasmania's first holiday season fatality has brought the nation's road toll to 22.
A man died in single-vehicle crash at Latrobe, in Tasmania's north, shortly after 6am (AEDT) on Thursday.
Six people have died on Victoria's roads since December 21 - the highest state holiday road toll so far.
Five people have died in NSW, five in WA, two in South Australia, and one in Queensland, the Northern Territory, the ACT and Tasmania.
Fatal crashes in southern NSW on Wednesday claimed two more lives, bringing the state's road toll to five.
Two cars travelling in opposite directions collided about 6.30pm (AEDT) on the Kings Highway between Bungendore and Braidwood, east of Queanbeyan.
The 54-year-old male driver of a Volvo was trapped in the wreckage for about three hours and died in Canberra Hospital about 11pm.
In a separate crash at Unanderra, south of Wollongong, a motorcyclist died after losing control of his bike and crashing into a road barrier about 5pm on Wednesday.
The 35-year-old was airlifted to St George Hospital but died shortly before 9pm.
On Wednesday at Kalgoorlie, 600km east of Perth, a woman died after a rear tyre on her Daihatsu sedan exploded, causing the car to roll.
The car left the road, skidded and then rolled at least once before coming to rest upright on its tyres.
The woman was wearing a seatbelt but died at the scene from massive head injuries.
In the Northern Territory, a 16-year-old girl died after she was struck by a car.
Police believe the girl was lying on Robinson Road at Borroloola, in the Gulf of Carpentaria region, when she was struck by a car at about 12.30am (CST) on Wednesday.